Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF. Since 5-MTHF also contributes to the production of serotonin, melatonin, dopamine, epinephrine, and norepinephrine, supplementation supports healthy mood.*
It is important for a woman not just those women who are planning to become pregnant.*Folic acid intake is especially important before conception and during early pregnancy, since its biggest need is during the first trimester – when a woman might not even know she is pregnant. Supplementation with the active form of folic acid – 5-MTHF (L-5 Methyltetrahydrofolate)– is always preferable.
Acting with vitamin B12, 5-MTHF functions as a methyl-group donor, thereby facilitating the conversion of the amino acid homocysteine to methionine.* Methyl-group donation is vital to many biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA.
ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY WARNING If pregnant, consult your health professional before using this product.
INTERACTIONS 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.